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This page was prepared by Lynn Kash, RN, Internet Nursing Guide
Pennsylvania Nurses,Emergency Department
http://www.nursefriendly.com/kash/

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Bravelle(Urofollitropin for injection), Alternative Fertility Treatment Approved, Advance for Physician Assistants:"Bravelle (urofollitropin for injection) by Ferring Pharmaceuticals has received approval from the U.S. Food and Drug Administration. Bravelle is a highly purified, human-derived follicle-stimulating hormone (hFSH) for the treatment of infertility. It is indicated for ovulation induction following pituitary suppression in conjunction with human chorionic gonadotropin."
http://www.advanceforpa.com/PharmUpdate/july02.html

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Bravelle(Urofollitropin for injection, purified), General Information, Center Watch:"Bravelle, approved in May 2002 for the treatment of infertility, is a highly purified, human-derived follicle-stimulating hormone (hFSH) indicated for ovulation induction following pituitary suppression. It is used in conjuction with human chorionic gonadotropin. Bravelle is available for both subcutaneous and intramuscular injection."
http://www.centerwatch.com/patient/drugs/dru778.html

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Bravelle(Urofollitropin for Injection, Purified), FDA Approves Bravelle (Urofollitropin for Injection, Purified) Ferring's New Human-Derived Follicle-Stimulating Hormone For Infertility Treatment, May 7, 2002, Doctor's Guide:"With the introduction of Bravelle™, Ferring has expanded its family of human-derived hormones to include a highly purified, well-tolerated hFSH with proven efficacy in ovulation induction, a critical step in many infertility treatment protocols," said Wayne Anderson, president of Ferring Pharmaceuticals. "Based on the fact that recombinant technology has shown no meaningful advantage in either efficacy or safety in the clinic, Ferring remains committed to the development of human-derived products in order to seek improvements in ovarian stimulation protocols."
http://www.pslgroup.com/dg/215426.htm

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Bravelle(TM)(Urofollitropin for Injection, Purified), Fertility Products, Ferring Pharmaceuticals:"Bravelle is the newest highly purified human-derived FSH (hFSH). It is the only human-derived FSH approved for both subcutaneous (SC) and intramuscular (IM) injection. Bravelle in conjunction with human chorionic gonadotropin, is indicated for ovulation induction following pituitary suppression."
http://www.ferringusa.com/fertility_products/

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Bravelle(TM)(Urofollitropin for Injection, Purified), New Highly Purified Alternative To Genetically Engineered Infertility Treatments, May 6, 2002, Franklin Drug Center:"Ferring Pharmaceuticals, a world leader in naturally occurring protein hormones, announced today that it has received approval from the U.S. Food and Drug Administration (FDA) to market Bravelle™ (urofollitropin for injection, purified), a highly purified, human-derived follicle-stimulating hormone (hFSH) for the treatment of infertility. Bravelle™, in conjunction with human chorionic gonadotropin, is indicated for ovulation induction following pituitary suppression."
http://www.franklindrugcenter.com/bravelle.htm

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Urofollitropin(Bravelle), FDA Approves Fertility Treatment, Mosby's DRUG Consult:"Tarrytown, New York-based Ferring said its urofollitropin (Bravelle) induces ovulation when used with human chorionic gonadotropin following pituitary suppression. The company said approval was based in part on a trial in which Bravelle's safety and efficacy were equivalent to that of recombinant FSH. Bravelle is easier to manufacture than the recombinant versions and is expected to be priced significantly lower, Ferring said. The product, extracted from the urine of postmenopausal women, is highly purified. It is available as a subcutaneous or intramuscular injection.
http://www.mosbysdrugconsult.com/DrugConsult/newapp2002.html#n-FDAappInfTrea

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Bravelle, Indications, Pharmactives:": Prevention and treatment of postmenopausal osteoporosis. More Information: a new 35 mg once-a-week dosage strength for Actonel was approved. This approval offers patients the convenience of a once-a-week dosing option to manage their osteoporosis. It will be available in mid-June 2002, by prescription only."
http://www.pharmactives.com/mb/messageview.cfm?catid=5&threadid=118

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Urofollitropin(Bravelle), Infertility Treatment Wins FDA Approval, May 7, 2002, Reuters Health Information:"The approval was based in part on a trial in which Bravelle's safety and efficacy were equivalent to that of recombinant FSH, the company said. A spokesman for Ferring said that Bravelle is easier to manufacture than the recombinant versions and is expected to be priced significantly lower. The product is extracted from the urine of postmenopausal women and is highly purified. It is available as a subcutaneous or intramuscular injection. The spokesman said they expect Bravelle to be available in about 2 weeks. The company is also seeking additional indications in infertility treatment for Bravelle."
http://www.tripletconnection.org/infertility.html

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Bravelle, How it is used, WebMD.com:"Bravelle is a highly purified form of a human-derived follicle-stimulating hormone (hFSH). The hormone works by stimulating the ovaries to develop follicles (eggs) to assist in treating infertility. Bravelle is delivered by injection and is used in conjunction with another fertility treatment (human chorionic gonadotropin) to stimulate ovulation."
http://my.webmd.com/content/article/4048.145

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Bravelle, Drugs Used for Ovulation Induction, Women's Institute.org:"The second group of gonadotropin preparations to be developed was urine derived but highly purified. These included Metrodin (uFSH) initially and later, with a higher degree of purification, Fertinex and Bravelle. NegligableLH was present in these preparations. In addition, the absence of protein irritants allowed the drugs to be approved for subcutaneous administration."
http://www.womensinstitute.org/institute/ovulation-induction.html

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