Cognex (tacrine); healthsquare.com:"Cognex is used for the treatment of mild to moderate Alzheimer's disease. This progressive, degenerative disorder causes physical changes in the brain that disrupt the flow of information and affect memory, thinking, and behavior. As someone caring for a person with Alzheimer's, you should be aware that Cognex is not a cure, but has helped some people."
http://www.healthsquare.com/newrx/cog1091.htm

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Cognex (tacrine); NeuroSkills.com:"Mechanism of Action: Presumably acts by elevating acetylcholine concentrations in the cerebral cortex by slowing the degradation of acetylcholine. Therapeutic Use: Treatment of mild to moderate Alzheimer dementia (impaired intellectual functioning). Absorption: Rapidly absorbed after oral administration. Maximal plasma concentration is reached in 1-2 hours. Metabolism: Extensively metabolized by the cytochrome P-450 system to multiple metabolites, not all of which have been identified. Half-life: 2-4 hours. Average Daily Dose (adult): Initial dose is 40 mg/day (10 mg QID)."
http://www.neuroskills.com/index.html?main=tbi/pharm.shtml

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Cognex (tacrine); Biopsychiatry.com:"This review provides no convincing evidence that tacrine is a useful treatment for the symptoms of Alzheimer's disease. However, as so few trials presented data in a format suitable for pooling, the results of this review may be modified when further data from all relevant trials are included. There is an urgent need for the independent evaluation of the data already existing in the trials but not accessible through published or grouped data."
http://www.biopsychiatry.com/tacrine.htm

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Cognex (tacrine); benbest.com:"acetylcholine (primarily from the nucleus of Meynert in the basal forebrain) acts as a neurotransmitter to stimulate the hippocampus, memory function can be improved somewhat by substances that facilitate acetylcholine production -- particularly in Alzheimer's patients. No cholinergic agonists have been successful in simulating this effect, but some acetylcholinesterase (acetylcholine-destroying enzyme) antagonists like tacrine have been."
http://www.benbest.com/lifeext/smart.html

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Cognex (tacrine); personalmd.com:"This medication is used to treat Alzheimer's disease. For best absorption, tacrine should be taken on an empty stomach, 1 hour before, or two hours after meals. If stomach upset occurs, it may be taken with meals, however, food can decrease tacrine blood levels significantly. Follow all instructions exactly. Nausea, vomiting, diarrhea, heartburn, muscle aches, loss of appetite and loss of balance may occur. Contact your doctor if these persist or are disabling. Tell your doctor immediately if the following occur: rash, jaundice (yellowing of eyes or skin), changes in stool color or stomach pain. Very unlikely but report promptly any unusually slow pulse, seizures or unusual change in amount of urine. If you notice other effects not listed above, contact your doctor or pharmacist."
http://www.personalmd.com/drgdb/218.htm

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Cognex (tacrine); nootropic.com:"To examine the antagonism of tacrine on the amnesic effects of scopolamine (Sco), anisodine (AT3), atropine (Atr), and anisodamine (Ani). METHODS: Cognitive functions and locomotor activities were determined using two sessions of step-through and open-field tests, respectively. Mice were injected with one of the belladonna alkaloids (0.05-50 mumol.kg-1, i.p.) and tacrine (50 mumol.kg-1, s.c.) 30 min before the first session. RESULTS: Tacrine completely blocked the avoidance-learning deficit caused by Sco 0.5 mumol.kg-1, AT3 and Atr 5 mumol.kg-1, or Ani 50 mumol.kg-1. But tacrine partly antagonized the learning deficit induced by Sco 5-50 mumol.kg-1 or Atr and AT3 50 mumol.kg-1."
http://nootropic.com/tacrine/index.html

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Cognex (tacrine); zarcrom.com:"Primary medical role: Improve cognitive symptoms in early Alzheimer's disease. Role in Alzheimer's disease: Increase cognition in mild to moderately demented Alzheimer's disease. Approved by FDA for Alzheimer's use?: Yes. Pharmacological role: Acetylcholinesterase inhibitor. Contraindications: Liver disease."
http://www.zarcrom.com/users/alzheimers/tac.html

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Cognex (tacrine); MedlinePlus.com:"Tacrine is used to treat the symptoms of Alzheimer's disease, but it does not cure the disease. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. How should this medicine be used? Tacrine comes as a capsule to take by mouth. It usually is taken four times a day. Take tacrine on an empty stomach (1 hour before or 2 hours after meals). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tacrine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor."
Office of Communications and Public Liaison National Library of Medicine
8600 Rockville Pike Bethesda, Maryland 20894
Phone: (301) 496-6308 Fax: (301) 496-4450 email: publicinfo@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a693039.html

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Cognex (tacrine); pccnaturalmarkets.com:"Interactions with Dietary Supplements: Vitamin C:Tacrine can cause reversible liver damage in some people who take the drug. Test tube studies have shown that vitamin C blocks the formation of cell-damaging substances produced when tacrine is broken down by the body.1 Controlled studies are needed to determine whether supplemental vitamin C might prevent liver damage in people taking tacrine."
http://www.pccnaturalmarkets.com/health/Drug/Tacrine.htm

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Cognex (tacrine); drugguide.com:"NURSING IMPLICATIONS: Assessment:Assess cognitive function (memory, attention, reasoning, language, ability to perform simple tasks) throughout therapy. Monitor nausea, vomiting, anorexia, and weight loss. Notify health care professional if these side effects occur. Potential Nursing Diagnoses:Thought processes, altered (Indications); Nutrition, altered: less than body requirements; Knowledge deficit, related to medication regimen (Patient/Family Teaching). Patient/Family Teaching:Instruct patient and caregiver that medication should be taken as directed. Advise patient and caregiver to notify health care professional if nausea, vomiting, anorexia, and weight loss occur. Evaluation: Clinical response indicated by: Temporary improvement in cognitive function (memory, attention, reasoning, language, ability to perform simple tasks) in patients with Alzheimer’s disease."
http://www.drugguide.com/classification_articles/anti-alzheimeragents.htm

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