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Oxaliplatin, Introduction, CancerBACUP.com:"Oxaliplatin is a chemotherapy drug that is given as a treatment for some types of cancer. This factsheet describes oxaliplatin, how it is given and some of its possible side effects. It will help you to read it with CancerBACUP's booklet Understanding Chemotherapy, which gives more information and advice. Oxaliplatin is often given in combination with another chemotherapy drug known as 5-FU. CancerBACUP has a factsheet on 5-FU which we would be pleased to send you. http://www.cancerbacup.org.uk/info/oxaliplatin.htm

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Eloxatin, Eloxatin Receives Expanded Indication For Metastatic Colorectal Cancer, May 6, 1998, Doctor's Guide:"Sanofi announced today that oxaliplatin, marketed in France under the trademark Eloxatin(R), has been approved in France as a first-line treatment for metastatic colorectal cancer in association with fluoropyrimidines and as the sole treatment in patients for whom the administration of fluoropyrimidines is not appropriate."
http://www.pslgroup.com/dg/799fa.htm

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Eloxatin,FDA APPROVES ELOXATIN FOR COLORECTAL CANCER, August 12, 2002, Food and Drug Administration News:"The Food and Drug Administration (FDA) today announced the approval of Eloxatin (oxaliplatin) injection for use in combination with infusional 5-fluorouracil (5-FU) and leucovorin for the treatment of patients with colorectal cancer whose disease has recurred or become worse following initial therapy with a combination of irinotecan with bolus 5-FU and leucovorin. The combination including Eloxatin was shown to shrink tumors in some patients and delay resumed tumor growth. There are as yet no data on the effects of the combination on survival."
http://www.fda.gov/bbs/topics/NEWS/2002/NEW00825.html

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Eloxatin, Eloxatin to Treat Colon Cancer, August 13,2002, Health Scout News:"In the fastest review ever, the U.S. Food and Drug Administration has approved the use of a drug to fight colon cancer, the nation's second-leading cause of cancer death. Eloxatin is a last-ditch treatment, to be used when all other treatment options have failed. And its success rate hasn't been stellar. Only 9 percent of patients who received the drug had their tumors shrink measurably. Even then, the treatment was good only for about two months, when the tumors resumed their growth."
http://www.healthscoutnews.com/view.cfm?id=508556

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Eloxatin(Oxaliplatin), New Drug for Colorectal Cancers September 6, 2002, Nursing Spectrum:"With record speed, the federal Food and Drug Administration approved Eloxatin (oxaliplatin) as part of a chemotherapy combination that includes 5-fluorouracil (5-FU) and leucovorin for patients with advanced colorectal cancers that failed to respond to standard treatment. The drugs are effective only when taken in combination."
http://nsweb.nursingspectrum.com/NurseNewsEzine/DrugNews/index.cfm

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Eloxatin, Chemotherapy, OncologyChannel.com:"Eloxatin (oxaliplatin) is a platinum-based anticancer drug used to treat colorectal cancer that has recurred or advanced colorectal cancer. It is administered intravenously in combination with 5-fluorouracil plus leucovorin (5FU/LV). Temporary side effects include numbness or tingling in the fingers, toes, throat, and around the mouth. Eloxatin can also cause nausea, tiredness, mouth sores, and a temporary reduction in bone marrow function that results in low red blood cell, white blood cell, and platelet counts."
http://www.oncologychannel.com/coloncancer/treatment.shtml

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Eloxatin Infusion, Dosage and Administration, Pharmaceutical Journal:"For adults only. Recommended dose is 85mg/m2 intravenously repeated every two weeks. Adjust dosage according to tolerability. Always administer before fluoropyrimidines. Administer as a two to six hour intravenous infusion in 250-500ml glucose solution 5 per cent. See SPC for details on reconstitution."
http://www.pharmj.com/Editorial/19990925/products/eloxatin.html

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Eloxatin, Colon Cancer, TheRubins.com:"Eloxatin was approved for use in combination with 5-FU in patients who failed to respond to the combination of 5-FU and irintecan now used for initial cancer therapy. The trial of the drug involved 463 patients and was used in combination with and compared to 5-FU alone. In the trial the combination of the drugs shrank tumors by at least 30 % in 9 % of patients, while either 5-FU or Eloxatin alone shrank the tumors in virtually none of the patients. The combination of Eloxatin and 5-FU also kept tumors from starting to grow again for 4.6 months, or 2 months longer than for 5-FU alone."
http://www.therubins.com/illness/colon.htm

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Eloxatin®(Oxaliplatin), Oncology, Sanofi-Synthelabo:"Eloxatin® possesses the same mechanism of action as other platinum derivatives, but differs in terms of its activity and safety. Eloxatin® is the only platinum derivative effective in the treatment of colorectal cancer. The addition of Eloxatin® to 5-fluorouracil doubles the remission rate, extends progression-free survival by 3 months and prolongs overall median survival by a median length of at least 16 months, without impairing quality of life."
http://www.sanofi-synthelabo.com.ph/products_oncology.shtml

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